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It had all the elements of the kind of fraud we are n the lookout for today, but back then were essentially unheard of – ghostwriting [Sally Laden], corrupt KOLs [Charles Nemeroff], flooding of the literature, etc. The discontinuation symptoms [withdrawal] was first reported in 1994, and in a wave of articles in 1995, but didn’t really get appropriate attention until the 2001 report by Haddad: Discontinuation symptoms are recognised with tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors (SSRIs) and miscellaneous antidepressants. A wide variety of symptoms have been described, differing somewhat between antidepressant classes, and several symptom clusters or discontinuation syndromes appear to exist. A common feature is onset within a few days of stopping the antidepressant or, less commonly, reducing the dosage. Discontinuation syndromes are clinically relevant as they are common, can cause significant morbidity, can be misdiagnosed leading to inappropriate treatment and can adversely effect future antidepressant compliance. Preventative strategies include tapering antidepressants prior to stoppage and educating patients and healthcare professionals to ensure that antidepressants are taken consistently and not stopped abruptly. Most reactions are mild and short-lived and require no treatment other than patient reassurance. pid=20601103&sid=ac VRDi Rc YWz Q&refer=news Antidepressants Cut Effectiveness of Tamoxifen in Breast Cancer By Lisa Rapaport May 30 (Bloomberg) — Tamoxifen, a breast cancer medicine used by millions of women, doesnt work when taken with antidepressants like Eli Lilly & Co.s Prozac, Pfizer Inc.s Zoloft and Glaxo Smith Kline Plcs Paxil, a study says. 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