Chloroquine retinopathy after drug cessation

Discussion in 'Plaquenil' started by volod, 29-Feb-2020.

  1. NastyaW XenForo Moderator

    Chloroquine retinopathy after drug cessation


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Jan 05, 2020 In general, hydroxychloroquine and chloroquine retinopathy are not reversible, and even following drug cessation, cellular damage appears to continue for a certain period of time. However, the earlier the retinopathy is recognized, the greater the chance of visual preservation. Keratopathy has been reported to be fully reversible. References Jun 11, 2009 The American Academy of Ophthalmology has suggested guidelines in order to monitor patients on hydroxychloroquine therapy, recommending a baseline dilated fundus exam, automated macular perimetry and Amsler grid testing. 3 Patients should be monitored annually, as toxicity can be irreversible and even progress after drug cessation. Jul 30, 2019 Most of the patients described were African or of African descent with dark skin who had been exposed to the sun. One was a Hispanic patient who developed vitiligo-like skin depigmentation after 1 month of chloroquine therapy for cutaneous lupus erythematosus. The skin rapidly repigmented after discontinuation of chloroquine therapy.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine retinopathy after drug cessation

    Expanded spectral domain-OCT findings in the early detection., Common Medications That May Be Toxic to the Retina

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  5. After the cessation of chloroquine treatment, early subtle macular changes can revert to normal. Although far advanced cases may progress despite discontinuation of the drug, most patients remain stable with long-term follow-up. 41,42 Chloroquine, however, is very slowly excreted from the body.

    • Chloroquine Retinopathy - an overview ScienceDirect Topics.
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    • Retinal toxicity associated with chronic exposure to hydroxychloroquine..

    Sep 15, 2014 Clearance of the HCQ from blood and urine can take months to years after drug cessation and visual function may continue to deteriorate slowly even after the therapy was stopped. Hydroxychloroquine Retinopathy. Chloroquine retinopathy was described for the first time in the early ’60s. Chloroquine CQ has been used widely for the treatment of rheumatoid arthritis RA and significant central visual loss associated with this drug has been reported 1. Prevalence of CQ maculopathy was 13.5% among RA patients taking CQ. Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes. It was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body. 2

     
  6. Snuppy New Member

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Plaquenil Hydroxychloroquine Side effects, Images, Uses. Lupus Board Index is plaquenil a blood thinner
     
  7. drumbase Moderator

    Mylan-Hydroxychloroquine - Uses, Side Effects. Mylan-Hydroxychloroquine Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints.

    Plaquenil Hydroxychloroquine Sulfate - Sanofi