I've been taking it for about 6 months now, and I can't tell that it's done a thing. I think I may be overmedicated and was thinking about dropping the plaquenil if there was no benefit to it. Thanks, Elcamino Hi Elcamino, I have been taking Plaquenil (400 mg per day) for about 2 years now due to lupus flare. Plaquenil side effects increased appetitie Plaquenil lupus dose How long does it take for plaquenil to work - Kim.luck. I'm crossing my fingers with you. Hopefully you can get back to Plaquenil and it will work for you. I had almost no side effects except for an minor upset stomach if I didn't eat when taking the pill. I think we're lucky there are drugs to Damage to the retina, the light sensitive portion of the inner eye, can occur with long-term use of Plaquenil or chloroquine Aralen. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. Donald E. Thomas Jr. MD, FACR, FACP, a practicing rheumatologist in Greenbelt, Md. and author of The Lupus Encyclopedia, regularly prescribes Plaquenil to his lupus patients. “We know that people with lupus who take their Plaquenil regularly are much more likely to live a long, normal life compared with those who don’t,” he says. Actually I started on 200 mg per day and about 2 months before tapering off pred, he upped me to 400 mg per day of plaquenil to give it plenty of time to kick in. When i first started it, I was also started on prednisone to get my inflammation under control. How long does plaquenil take to work for ra Hydroxychloroquine Side-effects, uses, time to work, Treating Lupus with Anti-Malarial Drugs Johns Hopkins. What medicines target same receptors as plaquenilAnti malarial tablets chloroquineHydroxychloroquine also called User Reviews for Plaquenil to treat Rheumatoid Arthritis. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. Plaquenil User Reviews for Rheumatoid Arthritis at. Protecting your eyesight when taking Plaquenil Lupus.. Plaquenil for RA?" Rheumatoid Arthritis Community.. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Health related message boards offering discussions of numerous health topics including allergies. how long does it take for plaquenil to work 14 replies Methotrexate vs plaquenil side effects long term and short term. Rheumatoid Arthritis. Dec 25, 2007. Aug 16, 2010 Hi everyone, I was just wondering how long it took for Plaquenil to start working for you? I've been on it for about a month now, and it hasn't worked for me yet, but I know that it can take up to 4 months to kick in.