Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. Plaquenil and sun exposure Chloroquine effect on lysosomes Summary Breast cancer is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take medication Enbrel, and have High blood pressure. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. Please check with the appropriate physician regarding health questions and concerns. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Plaquenil and cancer risk Long-Term Side Effects of Plaquenil for Rheumatoid., Rx Side Effects New Plaquenil Guidelines and More - American. Plaquenil lupus hair lossSulfasalazine vs plaquenil One study found methotrexate may be tied to melanoma, non-Hodgkin's lymphoma, and lung cancer. A second found that if you have RA and had a nonmelanoma growth in the past, you might have a greater chance of getting nonmelanoma skin cancer. The risk may be even higher if you take methotrexate with a TNF inhibitor. RA Drugs and Cancer What’s the Link?. The Risk of Retinal Toxicity with Plaquenil. Effects of chronic exposure of hydroxychloroquine.. Plaquenil Guidelines Point Out New Risks, New Presentation Written By Jean Shaw, Senior Editor, interviewing Rebekah A. Braslow, MD, Sang Jin Kim, MD, and Michael F. Marmor, MD Add to My To-Do List An increased risk for a serious disease, even if it’s small, needs to be considered when deciding to take any medication. But Dr. Matteson reminds his patients that poorly controlled RA not only damages joints, but raises the risk for heart disease and other threats. lives of individuals with arthritis. Aug 02, 2010 Yes, Plaquenil suppresses the immune system. Autoimmune disease such as Sjogrens occurs when the body gets "confused" and attacks healthy tissue instead of just attacking the germs. Basically, the immune system is a bit out of control. Plaquenil works by suppressing the immune system.