Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine malaria Plaquenil and radiation Chloroquine CQ treatment induces the apoptosis of liver cancer cells. HepG2 and Huh7 cells were treated with CQ for 72 h. A Apoptosis was determined by Annexin V-FITC/PI double-staining analysis. Aug 19, 2014 Where and How Chloroquine Fights Cancer. Chloroquine is an antimalaria drug that also suppresses tumor growth and metastasis. Chloroquine neutralizes the pH of intracellular compartments, thereby disrupting the endosomal trafficking and lysosomal function. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. Chloroquine CQ, the worldwide used anti-malarial drug, has recently being focused as a potential anti-cancer agent as well as a chemosensitizer when used in combination with anti-cancer drugs. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Chloroquine and liver cancer PPT1 promotes tumor growth and is the. - Cancer Discovery, Where and How Chloroquine Fights Cancer Science Signaling Plaquenil lupus remission A severe and sometimes deadly reaction has happened. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. If you have questions, talk with the doctor. This drug may add to the chance of getting some types of cancer. Chloroquine - Memorial Sloan Kettering Cancer Center. Chloroquine plaquil combinations - Ovarian cancer - Inspire. Porphyria Cutanea Tarda Pictures, Treatment, and More. No history of a previous invasive cancer in the last five years with the exception of minimally invasive non-melanoma skin cancer. Normal liver function based on Liver Function Tests Total Bilirubin and AST 1.5 X Upper Limit of Normal. Normal WBC 3.5-10.8 x 103µL, PLT 140-400 x 103µL, and HCT 37-52% My oncologist will not allow me to add a targeted therapy or chemo while on this regimen and is very reluctant to prescribe chloroquine or a derivative to me. We settled on hydroxychloroquine which seems to work as well as chloroquine phosphate. I tried adding artemisinin and it seems to help although I can tell it is too hard on my liver. Realizing that profuse activation of autophagy may contribute to pancreatic tumor growth, researchers designed an experiment in which they planned to treat the pancreatic cancer cell lines with Chloroquine, already known as inhibitor of autophagy. As a control, chloroquine was also used to treat normal cell lines with low expression of autophagy.