Chloroquine and liver cancer

Discussion in 'International Pharmacy' started by AISearch, 04-Mar-2020.

  1. FilmzIn Well-Known Member

    Chloroquine and liver cancer


    Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

    Chloroquine malaria Plaquenil and radiation

    Chloroquine CQ treatment induces the apoptosis of liver cancer cells. HepG2 and Huh7 cells were treated with CQ for 72 h. A Apoptosis was determined by Annexin V-FITC/PI double-staining analysis. Aug 19, 2014 Where and How Chloroquine Fights Cancer. Chloroquine is an antimalaria drug that also suppresses tumor growth and metastasis. Chloroquine neutralizes the pH of intracellular compartments, thereby disrupting the endosomal trafficking and lysosomal function. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. Chloroquine CQ, the worldwide used anti-malarial drug, has recently being focused as a potential anti-cancer agent as well as a chemosensitizer when used in combination with anti-cancer drugs.

    Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria.

    Chloroquine and liver cancer

    PPT1 promotes tumor growth and is the. - Cancer Discovery, Where and How Chloroquine Fights Cancer Science Signaling

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  3. A severe and sometimes deadly reaction has happened. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. If you have questions, talk with the doctor. This drug may add to the chance of getting some types of cancer.

    • Chloroquine - Memorial Sloan Kettering Cancer Center.
    • Chloroquine plaquil combinations - Ovarian cancer - Inspire.
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    No history of a previous invasive cancer in the last five years with the exception of minimally invasive non-melanoma skin cancer. Normal liver function based on Liver Function Tests Total Bilirubin and AST 1.5 X Upper Limit of Normal. Normal WBC 3.5-10.8 x 103µL, PLT 140-400 x 103µL, and HCT 37-52% My oncologist will not allow me to add a targeted therapy or chemo while on this regimen and is very reluctant to prescribe chloroquine or a derivative to me. We settled on hydroxychloroquine which seems to work as well as chloroquine phosphate. I tried adding artemisinin and it seems to help although I can tell it is too hard on my liver. Realizing that profuse activation of autophagy may contribute to pancreatic tumor growth, researchers designed an experiment in which they planned to treat the pancreatic cancer cell lines with Chloroquine, already known as inhibitor of autophagy. As a control, chloroquine was also used to treat normal cell lines with low expression of autophagy.

     
  4. optimizm New Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Effectiveness of Chloroquine and Hydroxychloroquine in. GABAPENTIN & HYDROXYCHLOROQUINE Multiple Sclerosis Society Will you have Multiple sclerosis with Plaquenil - eHealthMe
     
  5. FANZENIT XenForo Moderator

    Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Chloroquine and Hydroxychloroquine Maculopathy Case. Maculopathy - an overview ScienceDirect Topics Protecting your eyesight when taking Plaquenil Lupus.
     
  6. GERAsimov New Member

    Humanized anti-CD20 monoclonal antibody in the treatment. S ir, We present, to the best of our knowledge, the first case of a patient with severe resistant systemic lupus erythematosus SLE including the development of human antichimeric antibodies HACA after rituximab, who responded both clinically and serologically to an investigational humanized anti-CD20 monoclonal antibody hA20 provided on a.

    Hydroxychloroquine as an anti-thrombotic in.
     
  7. hulugurov XenForo Moderator

    Structure Activity Relationship of CHLOROQUINE Structure Activity Relationship of CHLOROQUINE. Addition of alpha diethylaminocresol in place of diethyl –diamino pentane results in production of amodiaquine, which is less toxics and also less effective as compared to chloroquine. Any substitution at position 1,2,5,6 will lead to decrease the pharmacological activity.

    Chloroquine phosphate C18H32ClN3O8P2 - PubChem