While the exact percentage of RA patients who experience sleep problems is hard to nail down, more than 80% of people with RA report fatigue as part of their symptoms. Why Sleep Matters Sleep problems can increase levels of stress hormones and aggravate flares, says Rochelle Rosian, MD, a Cleveland Clinic rheumatologist. Plaquenil irritability Doxycycline and hydroxychloroquine Chloroquine atom number Plaquenil and methotrexate for rheumatoid arthritis Drowsiness is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 1 month, also take medication Enbrel, and have Pain. Plaquenil can make you completely blind! *Legitimate looking vitamins I take to help remediate it I took Plaquenil for over 13 years and it caused me and 6 in every 1000 patients, new research shows to have toxic maculopathy it caused. *re even if you quit taking the drug, it can continue to damage the eye until blindness occurs. Plaquenil What You Need to Know. Contents What is Plaquenil. If you have psoriasis, Plaquenil may make your condition worse. Talk to your doctor if you have this condition. You can also monitor yourself between visits with a special grid called an Amsler grid, which can be obtained through your ophthalmologist. “When you sleep, you make all those brain chemicals that you need to feel better. And even if you’re not flaring, you may not manage your pain as well if you’re not sleeping. Does plaquenil make you sleepy Hydroxychloroquine Oral Route Description and Brand Names., PLAQUENIL Side Effects, Reviews by Patients - Plaquenil skin reactionPercentage of people with hair loss on plaquenilChloroquine synthesis reaction One is the steroid prednisone, which can cause insomnia, agitation or depression. Taking it earlier in the day is best, says Dr. Rosian. Another is hydroxychloroquine Plaquenil. “It’s a mild arthritis medicine,” says Dr. Fong, “so I’m usually not giving it to people who are really ill. Rheumatoid Arthritis and Sleep Arthritis Foundation. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Does Plaquenil cause fatigue or fever? - Rheumatoid Arthritis. May 25, 2010 Meds Celexa once a day, Buspar 2x a day, Levoxyl once a day, Metoprolol once a day, Lyrica 3x a day, Plaquenil 2 times day, Clonazepam to help me sleep for the moment until I find something else. Allergic to Sulfa, Ceftin, Augmentin, and Synthroid probably the filler. If you have one - it should have possible side effects listed. If not - you could try using a search engine. Type in Plaquenil + side effects and something should come up. Upset stomach initially is pretty common although not everone suffers it. Do always take with food. Take care - Scottie You can look up the therapeutic doses online and it will tell you the highest dose you can take. Normally the dose for lupus is 400mg daily. Maybe that is why you are so tired after taking them. I doesnt normally cause drowsyness but pred. causes me to be tired sometimes too. Drugs can affect everyone differently.