I'm currently on plaquenil 400mg daily and methotrexate 25mg weekly`many thanks in advance Did you tell the prescriber that you were on MTX? MTX should not be taken with any penicillin type drug. How do plaquenil look Lupus and plaquenil side effects Metabolic fate of chloroquine Several antibiotics appear to exert a strong effect on vitamin K activity, while others may not have any effect. Therefore, one should refer to a specific antibiotic for information on whether it interacts with vitamin K. Doctors of natural medicine sometimes recommend vitamin K supplementation to people taking antibiotics. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Hydroxychloroquine is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take hydroxychloroquine with a meal or a glass of milk. If you take these two medications together, your healthcare provider may need to monitor your cyclosporine levels and adjust your cyclosporine dosage as necessary. Digoxin Plaquenil may increase the level of digoxin in your blood, which can be quite dangerous. I'm honestly just curious because I've taken penicillin abx many times while on methotrexate... You also need to be very careful taking MTX with any type of chest infection and should not take it at all if you have pneumonia. I just finished pharmacology in nursing school, and also take methotrexate, and I've never heard that it shouldn't be taken with penicillin antibiotics - do you have any resources? Can you take antibiotics with hydroxychloroquine Is it safe to take amoxicillin with hydroxychloroquine., Hydroxychloroquine Uses, Dosage & Side Effects - Plaquenil and blindnessChloroquine phosphate for aquariumEye effects of plaquenil Antibiotics and meds. Support Forums. i'm currently on plaquenil 400mg daily and methotrexate 25mg weekly` many thanks in advance. He will not take me off MTX while taking antibiotic even penicillian because you are only on antibiotic about. 10 days and you would only miss one dose of MTX. It's still loaded in your system. Antibiotics and meds -. Drugs That Can Interfere With Plaquenil. Can I stop taking Hydroxychloroquine tablets and take.. Not for administration with other drugs that have potential to prolong QT interval; hydroxychloroquine prolongs QT interval; ventricular arrhythmias and torsades de pointes reported in patients taking hydroxychloroquine Skeletal muscle myopathy or neuropathy leading to progressive weakness and atrophy of proximal muscle groups. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. You can take Advil or another NSAID while taking Plaquenil hydroxychloroquine as long as NSAID isn't contraindicated for you. Asked in Health, Medication and Drugs, Antibiotics, Xanax.