Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Took plaquenil during pregnancy Chloroquine use and fluoroquinolone resistance dissertation Hemozoin chloroquine Hydroxychloroquine rob holland Oct 18, 2005 I was on Plaquenil for 6 years with almost no side effects. However, after going off for about 2 years while they investigated the cause of eye problemsnot Plaquenil I had a lot of side effects when I re-started, including eye problems and had to stop the drug. So it can cause different things at different times to different people. If diarrhea came back I had to back off and wait a week to add it again. After 2 months I could take the full dose BUT I can't take it as one tablet in a.m. and one in p.m. I have to break it up and take it 4 times a day to get in the normal 2 200mg tablets per day. The dizziness got better although I still have it a little from time to time. The way I understand it the plaquenil causes some CNS irritability. I think I have a little of it but I will just hang in there cause I had my dosage increased from 200 to 400 and saw results starting after 1 month. For me the relief of some of the symptoms has been very slight improvement that has increased slowly over time. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil cause dizziness after 2 years Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis., Plaquenil and dizziness DailyStrength Plaquenil red spots Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Irritability and increased hot flashes with Plaquenil. Plaquenil hydroxychloroquine sulfate Drug / Medicine.. Fever that happens while in or after coming back from the malaria area. What are some other side effects of Plaquenil? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. First, my mother and sister took plaquenil for lupus with good effect, so I am not just disliking it for no good reason. I also suffer from disabling bipolar disorder. For 25 years, I have gotten hypomanic during spring. Very happy, never depressed. When I started taking Plaquenil, I got a bit depressed but that's not a big deal. Rated Plaquenil for Rheumatoid Arthritis Report. After taking for 200 mg a day for about 2-3 months, my RA pains were much less. However i began suffering from vertigo and dizzy spells!