Chloroquine endocytosis

Discussion in 'Chloroquin' started by merera, 02-Mar-2020.

  1. Forrest Guest

    Chloroquine endocytosis


    It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic p H, and prevents fusion of endosomes and lysosomes. TLR7/8-Mediated Activation of Human NK Cells Results in Accessory Cell-Dependent IFN- Production.

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    In the present study we have examined the effects of artemisinin and the quinoline drugs chloroquine and mefloquine on endocytosis in Plasmodium falciparum. By using novel assays we found that mefloquine and artemisinin inhibit endocytosis of macromolecular tracers by up to 85%, while the latter drug also leads to an accumulation of undigested. Variations of endocytic and of lysosomal functions during the cell cycle have been investigated in synchronized hepatoma cells derived from Morris hepatoma 7288c by following the cellular uptake of horseradish peroxidase, dextran mol wt. 70,000, and chloroquine. However, little is known about how the endocytosis of GM1 is regulated. In this study, the treatment of PC12 cells with chloroquine at low μM concentrations induced marked GM1 accumulation whereas that at high μM concentration, which is required for the inhibition of lysosomal activity, induced the GM1 disappearance.

    Moreover, Chloroquine inhibits autophagy as it raises the lysosomal p H, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation [4]. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes [2, 3], such as the signaling of intracellular TLRs.

    Chloroquine endocytosis

    Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems., Endocytosis and chloroquine accumulation during the cell cycle of.

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  4. It is reported that betanodaviruses enter fish cells by endocytosis and the presence of 1 μmol/L chloroquine inhibits the entry and infection of betanodaviruses in vitro Adachi et al. 2007. Feline calicivirus FCV is a major causative agent of respiratory disease in cats.

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    Nov 29, 2016 Chloroquine is known to be a non-specific antiviral agent, but its effect on the Zika virus replication has not been evaluated yet. This is the first report of inhibitory effects of chloroquine on ZIKV replication, which, given the ongoing epidemics, may become interesting both for the scientific knowledge of the virus and for the clinical. Endocytosis occurs by a variety of mechanisms that are being dictated by the diversity of cargoes and cargo-specific transport kinetics, with the involvement of many genes. Table 1 lists the commonly studied genes involved in endocytosis and their antibodies cited among the articles in Labome's Validated Antibody Database. Jun 01, 2009 β-CD inhibits clathrin-dependent endocytosis by selectively extracting cholesterol from the plasma membrane. Hydrophobic amines such as phenothiazines, MDC and chloroquine inhibit clathrin-dependent endocytosis by affecting the function of clathrin and clathrin-coated vesicles Salisbury et al. 1980; Wang et al. 1993.

     
  5. Landr Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Stopping plaquenil. DailyStrength Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Plaquenil Oral Uses, Side Effects, Interactions, Pictures.
     
  6. SpaCh Guest

    In some cases, they may not be available in every strength or form as the brand-name drug. Plaquenil Risk Calculators Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Plaquenil hydroxychloroquine Alternatives & Similar.
     
  7. nimr New Member

    Plaquenil Dosage Guide - Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. In a small percentage of patients, side.

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  8. golitsin Well-Known Member

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    Hydroxychloroquine Oral Route Proper Use - Mayo Clinic