Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Hydroxychloroquine forum Chloroquine disposal down drain Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. OCT scan top of normal macula compared to Plaquenil Toxicity bottom with loss of the outer retinal tissue around the macular center red boxes View more retina images at Retina Rocks, the world’s largest online multimedia retina image library and bibliography repository. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Oct image plaquenil toxicity Plaquenil Side Effects Common, Severe, Long Term -, Hydroxychloroquine-Induced Retinal Toxicity - American. Aralen costoCalcium phosphate transfection chloroquinePlaquenil and breastfeeding lupus Time domain OCT does not have the resolution that spectral domain OCT has, making detection of hydroxychloroquine maculopathy by this modality less sensitive. Nevertheless, time domain OCT machines are more widely available, making it important to be able to recognize toxicity with this test. In this image, the perifoveal inner segment-outer segment junction has been lost at the purple arrows. Time Domain OCT in Hydroxychloroquine Plaquenil Toxicity - The Retina.. Plaquenil Toxicity - Bennett & Bloom Eye Centers. Plaquenil Toxicity - Mild - Partial Bull's Eye Maculopathy.. Click to email this to a friend Opens in new window Click to share on Twitter Opens in new window Click to share on Pocket Opens in new window The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience permanent vision loss resulting from hydroxychloroquine retinopathy due to improper dosing of the drug and improper screening. Image USC Roski Eye Institute. more than 5 years in whom we could document toxicity with OCT as well as visual fields and autofluorescence in different patients. the earliest possible.