Listing a study does not mean it has been evaluated by the U. One of the mechanisms responsible for survival of these therapy-resistant hypoxic cells is (macro-)autophagy: a phenomenon in which cells provide themselves with energy (ATP) by digesting their own cell-organelles. Tumor hypoxia is a well-known factor negatively influencing outcome in many solid tumors, including small cell lung cancer. Chloroquine phosphate in display tank Hydroxychloroquine cystic fibrosis Jan 01, 2013 Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the other hand, however, the kidneys are highly vulnerable to chemotherapeutic agents. Clinical trials may be studied as a treatment for cancer to meet certain that suite for different condition. Other people may choose other methods of cancer treatment, which usually is not FDA approved and often outside the United States. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the. Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. Clinical trials cancer chloroquine Chloroquine Clinical Trials, Side Effects AIDSinfo, Chloroquine and Cancer Treatment - Biomedical Research, A. Plaquenil pill dosagePlaquenil tablets prospectDoes prednisone and plaquenil work for ankylosing spondylititsPlaquenil cdc side effectsHow much is plaquenil with insurance Adjuvant Effect of Chloroquine on Gemcitabine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Adjuvant Effect of Chloroquine on Gemcitabine - Full Text.. Chloroquine in Cancer Therapy A Double-Edged Sword of.. Chloroquine reduces hypercoagulability in. - BMC Cancer. A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer CUBiC The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Clinical trials repurposing lysosomotropic chloroquine CQ derivatives as autophagy inhibitors in cancer demonstrate encouraging results, but the underlying mechanism of action remains unknown. Here, we report a novel dimeric CQ DC661 capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine. Jul 15, 2014 Along the lines of the Trial Watch series published on a monthly basis in OncoImmunology,35-38 here we summarize the dual role of autophagy in oncogenesis and tumor progression and discuss recent clinical trials investigating the use of chloroquine CQ, hydroxychloroquine HCQ in cancer patients.