Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Chloroquine ic 50 Plaquenil toxicity signs and symptoms Plaquenil perioperative Does plaquenil cause depression So that's the update. The lesson here is - for those who need to go off plaquenil, be careful about just going off it cold turkey. Obviously some of CAN do that, but if you don't know if you're one of them - better to be on the safe side and wean slowly. Take it from me! I am feeling much better after bumping my dose back up over the last few. With the Plaquenil I don't think you will find much relief in such a short time on it & at half of a workable dose. I have read about people stopping P & flaring up. Those who stopped it abruptly had real problems similar to what you are experiencing. If you really need to get off it, I would taper down slowly, very slowly. Plaquenil damps down the reactiveness of the receptors that send out your “fighters”, which in us is overactive. Rather than strangling the life out of your immune system like steroid meds do, it attenuates the function to closer to normal. Over time it can slightly lower your white cell count. Did you take yourself off Plaquenil, or did your doctor tell you to go off it? Plus I will be honest the whole eye site thing even though rare has always freaked me out. I went off of it to see if I can manage not being on it as my lupus isnt as severe as other cases but already I am feeling very fatigued and my legs feel heavy if that makes sense. I can discuss alternatives with my DR at my next appt but my DR feels as though the plaq is the best bet for my level of illness. If so are you just dealing with Lupus symptoms or did you take another med? I'm on Plaquenil, and after the first week's GI upset, I have had no problems with it. How to taper off plaquenil Healthboards - Immune & Autoimmune - Lupus tapering Plaquenil, Hydroxychloroquine plaquenil withdrawl? - LUPUS UK Plaquenil itching Jul 16, 2011 Has anyone's doctor suggested taking plaquenil to help taper off Rheum thinks that plaquenil will help me get to a lower dose of prednisone since I can't get past 7.5 mg without a flare. Has anyone taken plaquenil to taper off prednisone. - Inspire. Stopping Plaquenil - General Discussion - Life With Lupus. Taking Plaquenil for Rheumatoid Arthritis. Has anyone's doctor suggested taking plaquenil to help taper off Rheum thinks that plaquenil will help me get to a lower dose of prednisone since I can't get past 7.5 mg without a flare. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. Have been on methotrexate 20mg email@example.com for about a year and 1/2. Recently moved and have a new Rheumatoligist who did his own blood test and x-rays, according to him he cannot find the blood factor or damage to any joints to prove that I have RA. I would like to know can I stop taking methotrexate or do I have to ween off of it slowly? Or should I even be thinking of stopping the meds? I.