In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Hydroxychloroquine for dmard Hydroxychloroquine interactions Extinction coefficient chloroquine phosphate Pain relief from plaquenil Screening for hydroxychloroquine retinopathy The aim of screening is not to prevent retinopathy but to detect the earliest definitive signs of it before a patient notices any symptoms, because of this you have been invited to take part in the screening programme at the Eye Treatment centre. Where will the screening take place? Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings. Toxicity within the first five years of usage of the drug Revised guidelines recommend19 • Baseline examination within first year of usage of Plaquenil Hydrochloroquine or Aralen Chloroquine • Annual screening after 5 years of use **Interesting, The Royal College of Ophthalmologists in Great As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Plaquenil toxicity first screenin Plaquenil Uses, Dosage & Side Effects -, How to Succeed in Plaquenil Screenings Comparable drug to plaquenilChloroquine and proguanil brand The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. Plaquenil Risk Calculators. Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Protecting your eyesight when taking Plaquenil Lupus.. Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity. Doses lower than 5 mg/kg/day have low risk 1% for the first 5 years, and below 2% between 5-10 years of use. The longer you use the medication, the higher the risk of toxicity. Taking hydroxychloroquine. If you are already on the screening programme for hydroxychloroquine retinopathy, and your last screening tests were normal, it is very unlikely that your symptoms are due to hydroxychloroquine retinopathy. The next screening visit does not need to happen sooner than planned. However, The new guideline on screening for hydroxychloroquine and chloroquine retinopathy is written in response to evidence from the United States that shows that hydroxychloroquine retinopathy is more common than previously recognised. Implementation of the guideline’s recommendations will prevent iatrogenic visual loss. The new guideline also makes recommendations regarding the techniques and.